新学術領域「分子ロボティクス」
計測自動制御学会システム情報部門調査研究会「分子ロボティクス研究会」
DNAハイドロゲルの研究で著名なコーネル大学のDan Luo教授をお招きしてセミナーを開催いたします．
“DNA as an innovative nano-material” Prof. Dan Luo /Cornell University
- 日 時
- 7月6日（土曜日） 15:00-16:30
- 場 所
- 新学術「分子ロボティクス」田町オフィス CIC東京 5階 オープンスペース
- アクセス
- http://www.cictokyo.jp/
- お問い合わせ
- 村田 智（東北大学） murata@molbot.mech.tohoku.ac.jp
どなたでも参加できます．ふるってご参加ください．
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“DNA as an innovative nano-material”
Dan Luo
Departments of Biological and Environmental Engineering, Cornell
University, Ithaca, New York, 14853 USA. E-mail: DL79@cornell.edu
Abstract
Although our group has not worked on robotics per se, we have been
focusing on engineering DNA as a true polymer, which might provide
unique molecular tools and unprecedented materials for molecular
robotics. Inspired by polymers’ topologies and combined with molecular
biology’s tool kits, previously we have engineered DNA as a
nanomaterial into different topological forms including Y-shaped DNA,
dendrimer-like DNA, and networked DNA. From these DNA nanostructures,
we have created DNA nanobarcodes, DNA hydrogels, DNA liposomes
(DNAsomes), and DNA-organized nanoparticles. Many of these DNA-based
materials can be used as molecular sensing tools as well as molecular
delivery vehicles for cargos (including genes, siRNA, proteins, etc).
Recently we have also created a DNA hydrogel that can produce large
amounts of functional proteins without any living cells (termed
P-gel). Based on P-gel, we have further created functional
“quasi-cells” — compartmentalized structures that can be used to
mimic cells for protein production, engineering, and delivery. Most
recently, we have created a mechanical metamaterial that is based
entirely on DNA molecules. This metamaterial has both liquid and solid
properties and can return to its original shape even after unlimited
amorphous transitions. We believe that our DNA-based bulk materials
can be an invaluable tools and materials for the molecular robotics
field, and we are eager to collaborate.
Representative References:
1. Nature Nanotech. 7, 816-820 (2012)
2. Nature Communication 2, 587-590 (2011)
3. Nature Nanotech. 6, 268-276 (2011)
4. Nature Protocols 4, 1759-1770 (2009)
5. Nature Nanotech. 4, 430-436 (2009)
6. Nature Materials (Article) 8, 519-527(2009)
7. Nature Materials (Article) 8, 432-437 (2009)
8. Nature Nanotech. (Article) 3, 693-696 (2008)
9. Nature Materials 5, 797-801 (2006)
10. Nature Protocols 1, 995-1000 (2006)
11. Nature Biotechnology 23, 885-889 (2005)
12. Nature Materials 3, 38-42 (2004)
13. Nature Biotechnology 18, 893-895 (2000)
14. Nature Biotechnology 18, 33-37 (2000)